PNC-27 is a p53-derived peptide that selectively targets and kills cancer cells through MDM2 membrane interaction, investigated for selective apoptosis induction and cancer biology research.
| Purity | >98% |
| Form | Lyophilized powder |
| Storage | -20°C |
Science-backed research overview for this compound
PNC-27 is a "cancer-killing" peptide that contains a specific sequence from the p53 tumor suppressor protein. It is a dual-domain peptide designed to target the cell membrane of cancerous cells while leaving healthy cells untouched.
PNC-27 works by binding to the MDM2 protein, which is found in the membranes of many types of cancer cells but not in healthy cells. Once bound, the peptide causes the formation of pores (holes) in the cancer cell membrane, leading to rapid cell death (lysis) through osmotic pressure changes.
Laboratory research has shown that PNC-27 is effective against a wide range of human cancer cell lines, including breast, colon, and pancreatic cancer. Because it acts on the cell membrane rather than the DNA, it is being studied as a potential solution for drug-resistant cancers that have evolved to avoid traditional chemotherapy.