MOTS-c is a mitochondria-derived peptide that regulates glucose utilization, metabolic homeostasis, and insulin sensitivity. It is studied for its roles in aging, exercise physiology, and metabolic disease research.
| Molecular Weight | 2174.5 g/mol |
| Purity | >98% |
| Form | Lyophilized powder |
| Storage | -20°C |
Science-backed research overview for this compound
MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA — one of the first "mitochondrial-derived peptides" discovered. It is unique because it signals between the mitochondria and the cell nucleus to coordinate metabolic health.
MOTS-c activates the AMPK pathway, often called the "metabolic master switch." By doing so, it enhances glucose uptake and fatty acid oxidation, effectively mimicking the systemic benefits of physical exercise on the metabolism without direct activity.
As mitochondrial function declines with age, levels of MOTS-c also decrease. Research is focused on how MOTS-c can reverse age-related insulin resistance, prevent diet-induced obesity, and improve overall physical performance and lifespan in animal models.