KPV is the C-terminal tripeptide of alpha-MSH (Lys-Pro-Val) investigated for potent anti-inflammatory signaling, intestinal barrier function, IBD pathway modulation, and wound healing research.
| Molecular Weight | 341.41 g/mol |
| Purity | >98% |
| Form | Lyophilized powder |
| Storage | -20°C |
Science-backed research overview for this compound
KPV (Lysine-Proline-Valine) is a naturally occurring tripeptide that represents the C-terminal fragment of alpha-Melanocyte Stimulating Hormone (alpha-MSH). It is a potent anti-inflammatory molecule with no melanotropic (skin tanning) effects.
KPV works by entering the cell and interacting directly with inflammatory signaling pathways, specifically inhibiting the translocation of NF-kappaB. This prevents the cell from producing pro-inflammatory cytokines like TNF-alpha and IL-6, effectively shutting down the inflammatory response at its source.
Research into KPV focuses heavily on its role in treating Inflammatory Bowel Disease (IBD) and chronic skin conditions like psoriasis. It has shown the ability to repair the intestinal barrier, reduce colon inflammation, and accelerate the healing of wounds and skin lesions in research models.