ARA-290 is an 11-amino acid peptide derived from erythropoietin, engineered to activate the innate repair receptor without erythropoietic activity, investigated for neuroprotective and anti-inflammatory research.
| Purity | >98% |
| Form | Lyophilized powder |
| Storage | -20°C |
Science-backed research overview for this compound
ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide derived from erythropoietin (EPO). However, unlike EPO, it does not stimulate the production of red blood cells, making it a "non-erythropoietic" agent focused entirely on repair.
ARA-290 works by selectively activating the Innate Repair Receptor (IRR). This receptor is only expressed on cells during injury or inflammation. By activating the IRR, ARA-290 shuts down inflammatory pathways and triggers cellular survival and repair mechanisms.
Research into ARA-290 focuses on neuropathic pain and small fiber neuropathy. It has shown the ability to regenerate damaged nerve fibers and reduce chronic pain in research models of diabetes and sarcoidosis, offering a potential breakthrough in neuro-regenerative science.