5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor investigated for adipogenesis inhibition, NAD+ metabolism, and metabolic pathway research.
| Purity | >98% |
| Form | Powder |
| Storage | -20°C |
Science-backed research overview for this compound
5-Amino-1MQ is a small molecule that acts as a potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme found primarily in fat tissue. NNMT is a key regulator of metabolic rate and energy metabolism.
By inhibiting NNMT, 5-Amino-1MQ prevents the depletion of NAD+ and methyl groups. This increase in intracellular NAD+ enhances energy metabolism, increases fat oxidation, and triggers the expression of genes involved in mitochondrial biogenesis.
Research indicates that 5-Amino-1MQ can reverse high-fat diet-induced obesity by increasing the metabolic rate of white adipose tissue. It is studied for its ability to improve muscle function, increase lean mass, and support healthy aging by optimizing the NAD+ metabolome.